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La disminución de la sensibilidad al calcio de las arterias de resistencia inducida por el óxido nítrico es

Steffen-Sebastian Bolz1, Lukas Vogel, Daniel Sollinger

  • 1Physiologisches Institut der Ludwig Maximilians Universität, Schillerstrasse 44, 80336 München, Germany. bolz@lrz.uni-muenchen.de

Circulation
|June 11, 2003
PubMed
Resumen

El óxido nítrico (NO) dilata las arterias de resistencia mediante la activación de la miosina fosfatasa de cadena ligera (MLCP), reduciendo la sensibilidad celular al calcio. La vía RhoA contrarresta este efecto, pero los inhibidores de la Rho quinasa pueden restaurar la vasodilatación mediada por NO.

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