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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

Cambios de hidratación que acompañan a las reacciones de intercalación de ácido nucleico: caracterizaciones

Feixue Han1, Tigran V Chalikian

  • 1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, Ontario M5S 2S2, Canada.

Journal of the American Chemical Society
|June 12, 2003
PubMed
Resumen

La unión del etidio a estructuras de ácido nucleico como el ADN y el ARN causa cambios de volumen y compresibilidad. Estos hallazgos resaltan el papel crucial de la hidratación en las interacciones fármaco-ácido nucleico.

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