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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
Published on: July 16, 2012
Falta de inmunidad protectora contra la reinfección con el virus de la hepatitis C
P Farci1, H J Alter, S Govindarajan
1Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Science (New York, N.Y.)
|October 2, 1992
Resumen
La reinfección del virus de la hepatitis C (VHC) se produce en los chimpancés, lo que indica que no se desarrolla inmunidad protectora después de la infección inicial. Este hallazgo plantea preocupaciones para el desarrollo de vacunas efectivas contra la hepatitis C.
Área de la Ciencia:
- Hepatología Hepatología.
- Virología Virología.
- Inmunología Inmunología.
Sus antecedentes:
- La infección por el virus de la hepatitis C (VHC) puede conducir a hepatitis aguda recurrente.
- Se debate la causa de la hepatitis C recurrente: la reinfección frente a la reactivación viral.
Objetivo del estudio:
- Investigar si la infección por el virus de la hepatitis C (VHC) confiere inmunidad protectora contra infecciones posteriores.
- Para determinar si la hepatitis recurrente se debe a la reinfección o reactivación del virus original.
Principales métodos:
- Cinco chimpancés fueron inoculados secuencialmente con diferentes cepas del VHC durante 3 años.
- Los marcadores de replicación viral y las respuestas inmunes del huésped fueron monitoreados después de cada inoculación.
Principales resultados:
- El re-desafío con cepas homólogas o heterólogas del VHC resultó consistentemente en viremia.
- La viremia después de la reincidencia se atribuyó a la infección con el nuevo virus del reto.
Conclusiones:
- La infección por el VHC no induce inmunidad protectora contra la reinfección.
- La falta de inmunidad protectora plantea desafíos para el desarrollo de vacunas efectivas contra el VHC.
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