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Hipersensibilidad a la denervación colinérgica del músculo liso en la enfermedad diverticular
Mark Golder1, David E Burleigh, Abi Belai
1Academic Department of Surgery, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK. m.s.golder@qmul.ac.uk <m.s.golder@qmul.ac.uk>
Lancet (London, England)
|June 13, 2003
Resumen
La enfermedad diverticular está relacionada con la reducción de la actividad colinérgica neural y el aumento de los receptores M3 del músculo liso. Esto sugiere que la hipersensibilidad a la denervación colinérgica puede explicar las anomalías de la enfermedad.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- La neurogastroenterología y la gastroenterología.
- Fisiología del músculo liso Fisiología del músculo liso
Sus antecedentes:
- La patogénesis de la enfermedad diverticular puede implicar trastornos del sistema colinérgico.
- Los mecanismos precisos de la participación colinérgica siguen sin estar claros.
- Investigar el músculo liso y la actividad colinérgica neural es crucial.
Objetivo del estudio:
- Investigar el papel del músculo liso y la actividad colinérgica neural en la enfermedad diverticular.
- Para determinar si la hipersensibilidad a la denervación colinérgica está presente en la enfermedad diverticular.
Principales métodos:
- Análisis inmunohistoquímico de la colina acetiltransferasa y los receptores M3 en los tejidos del colon sigmoide de pacientes y controles.
- Experimentos de baño de órganos para evaluar la sensibilidad a la acetilcolina en tiras musculares.
Principales resultados:
- Disminuir la actividad de la colina acetiltransferasa tanto en el músculo liso circular como en el músculo liso longitudinal de pacientes con enfermedad diverticular.
- Receptores M3 upregulados en el músculo liso de pacientes con enfermedad diverticular.
- Aumento de la sensibilidad a la acetilcolina en el músculo circular, pero no en el músculo longitudinal, de pacientes con enfermedad diverticular.
Conclusiones:
- Los resultados sugieren hipersensibilidad a la denervación colinérgica en el músculo liso.
- La upregulación de los receptores M3 del músculo liso puede contribuir a las anomalías de la enfermedad diverticular.
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