Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Feedback Loops

Feedback Loops

In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.

Hormones Regulating Blood Glucose

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...

The ABO Blood Group

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...

Liver Physiology

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...

Protein Buffers in Blood Plasma and Cells

Protein Buffers in Blood Plasma and Cells

The human body utilizes protein buffer systems to maintain a stable pH. These systems capitalize on the dual role of amino acids, which can act as acids or bases by accepting or releasing hydrogen ions in response to pH changes. Protein buffer systems are particularly significant in the extracellular fluid (ECF) and intracellular fluid (ICF) of active cells, where structural and functional proteins provide substantial buffering capacity.
Certain amino acids can exist in a zwitterion state at a...

Glucose Homeostasis: Regulation of Blood Glucose

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Platelet glycoprotein VI modulates leukocyte characteristics in sepsis-induced systemic inflammatory response in male mice.

Physiological reports·2026

Same author

Efforts to Enhance Recruitment and Engagement of Caregivers from Medically Underserved Communities in a Randomized Controlled Trial of a Vaccine Promotion App.

Journal of clinical and translational science·2026

Same author

Identification and Characterization of Platelet Surface-membrane-derived Microparticles before and after Total-body Irradiation.

Radiation research·2025

Same author

Corrigendum to "Hesitancy and confidence in pediatric COVID-19 vaccination among diverse caregivers of unvaccinated children" [Vaccine 61 (2025) 127245].

Vaccine·2025

Same author

Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusion.

bioRxiv : the preprint server for biology·2025

Same author

Hesitancy and confidence in pediatric COVID-19 vaccination among diverse caregivers of unvaccinated children.

Vaccine·2025

Search research articles

Video Experimental Relacionado

Updated: Jul 12, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

Modulación de la función de la alfa-trombina por distintas interacciones con la glicoproteína plaquetaria Ibalphapha.

Reha Celikel¹, Richard A McClintock, James R Roberts

¹Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Thrombosis and Hemostasis, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)

|July 12, 2003

Resumen

La glicoproteína plaquetaria Ibalpha (GpIbalpha) se une a la trombina en dos sitios, lo que influye en el sangrado y la trombosis. Esta interacción también modula la trombina.

Más Videos Relacionados

An In Ovo Model for Testing Insulin-mimetic Compounds

An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Videos de Experimentos Relacionados

Last Updated: Jul 12, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

An In Ovo Model for Testing Insulin-mimetic Compounds

An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Área de la Ciencia:

La bioquímica es la bioquímica.
Biología Estructural Biología estructural.
Hematología Hematología.

Sus antecedentes:

La trombina juega un doble papel en la hemostasis y la trombosis.
La glicoproteína plaquetaria Ibalpha (GpIbalpha) es un receptor clave involucrado en la función plaquetaria.

Objetivo del estudio:

Para determinar la estructura de GpIbalpha unido a la alfa-trombina.
Para dilucidar los sitios de unión y los mecanismos de interacción entre GpIbalpha y la trombina.

Principales métodos:

Cristalografía de rayos X con una resolución de 2.3 angstroms.
Análisis estructural del complejo GpIbalfa-trombina.

Principales resultados:

Dos sitios de unión distintos en GpIbalpha interactúan con el exosito II y el exosito I de la alfa-trombina.
Se sugiere la unión secuencial, con el sitio de unión del exosito I expuesto después de la interacción inicial del exosito II.
El agrupamiento de GpIbalpha y la escisión del receptor activado por proteasa están mediados, mientras que la coagulación del fibrinógeno es potencialmente limitada.

Conclusiones:

La estructura revela un nuevo mecanismo para la regulación de la trombina mediada por GpIbalpha.
Estas interacciones son críticas para comprender la activación plaquetaria y la trombosis.
Dirigirse a estas interfaces puede ofrecer estrategias terapéuticas para los trastornos de la coagulación y el sangrado.