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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
Published on: December 7, 2021
Capacidad evolutiva como una característica general de las redes complejas de genes.
1Department of Biological Sciences, Stanford University, Stanford, California 94305-5020, USA.
Nature
|August 2, 2003
Resumen
La mayoría de los genes pueden actuar como condensadores evolutivos, amortiguando la variación genética y acelerando la adaptación. Este efecto amortiguador, a diferencia del Hsp90, no requiere cambios ambientales.
Área de la Ciencia:
- Biología evolutiva Biología evolutiva.
- Genética La genética.
- Biología molecular La biología molecular.
Sus antecedentes:
- Un condensador evolutivo amortigua la variación genotípica, escondiéndola hasta que el condensador falla.
- La proteína de choque térmico 90 (Hsp90) es un conocido condensador evolutivo, que suprime la variación fenotípica y la libera cuando está comprometida.
- La función de Hsp90 se ve afectada por el estrés ambiental y tiene efectos pleiotrópicos en el desarrollo.
Objetivo del estudio:
- Para investigar si la capacitancia evolutiva se limita a Hsp90 o si otros genes también pueden actuar como condensadores.
- Explorar el mecanismo y el alcance de la capacitancia evolutiva más allá de Hsp90.
- Para determinar si las mutaciones de pérdida de función en los genes aceleran la adaptación.
Principales métodos:
- Simulaciones numéricas de redes complejas de genes.
- Análisis de datos de expresión a escala genómica de cepas de levadura con deleción de un solo gen.
Principales resultados:
- La mayoría, si no todos, los genes pueden revelar variación fenotípica cuando están funcionalmente comprometidos.
- La disponibilidad de mutaciones de pérdida de función acelera la adaptación a nuevos fenotipos.
- Esta aceleración adaptativa no requiere mutaciones dependientes del entorno.
Conclusiones:
- Es probable que exista una amplia clase de condensadores evolutivos más allá de Hsp90.
- Estos condensadores complementan los efectos sistémicos inducidos por el medio ambiente de Hsp90.
- Comprender estos condensadores puede revelar nuevos conocimientos sobre los mecanismos de adaptación.
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