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Updated: Jul 12, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Macrolactonización a través del acoplamiento epoxi-ácido mediado por Ti(IV): una síntesis total de (-) -dactilolide

Thomas R Hoye1, Min Hu

  • 1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. hoye@chem.umn.edu

Journal of the American Chemical Society
|August 9, 2003
PubMed
Resumen

Este estudio detalla la síntesis total de dactilolide, con una nueva estrategia de acoplamiento mediada por Ti (IV). Los pasos clave incluyen la formación de anillos estereoselectivos y oxidaciones selectivas para construir arquitecturas moleculares complejas.

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