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Updated: Jun 25, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

Una ruta concisa a los macrolactones benzofusionados a través de los ynolidos: cicloparadicicol y cicloparadicicol

Zhi-Qiang Yang1, Samuel J Danishefsky

  • 1Laboratory for Bioorganic Chemistry, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

Journal of the American Chemical Society
|August 9, 2003
PubMed
Resumen

Un nuevo método de síntesis crea cicloparadicicol, un potente inhibidor de la proteína de choque térmico nanomolar 90 (Hsp90). Este avance utiliza la complejación de cobalto y las reacciones en tándem de Diels-Alder para el ensamblaje eficiente de macrolactona.

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