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Riesgo de recaída después de la vacuna conjugada meningocócica C en el síndrome nefrótico

A S Abeyagunawardena¹, D Goldblatt, N Andrews

¹Nephrourology Unit, Institute of Child Health, London, UK.

Lancet (London, England)

|August 21, 2003

Resumen

La vacuna meningocócica C conjugada (VCMC) se ofreció a los niños del Reino Unido. En pacientes con síndrome nefrótico, el MCCV aumentó significativamente las tasas de recaída, lo que justifica una cuidadosa consideración de la vacunación.

Área de la Ciencia:

Nefrología Pediátrica.
Inmunología Inmunología.
Vacunología La vacunología.

Sus antecedentes:

El síndrome nefrótico es un trastorno renal que afecta a los niños.
La vacuna meningococcica C conjugada (VCMC) se introdujo en el Reino Unido en 1999 para todos los niños menores de 18 años.
El impacto del MCCV en niños con síndrome nefrótico no estaba previamente bien establecido.

Objetivo del estudio:

Investigar el efecto de la vacuna meningococcica C conjugada (VCMC) en la tasa de recaídas en niños con síndrome nefrótico.

Principales métodos:

Se estudió una cohorte de 106 niños diagnosticados con síndrome nefrótico.
Las tasas de recaída se compararon durante los 12 meses anteriores y los 12 meses posteriores a la administración de MCCV.

Principales resultados:

Se registraron un total de 63 recaídas en los 12 meses anteriores a la vacunación.
El número de recaídas aumentó a 96 en los 12 meses posteriores a la administración de MCCV.
Este aumento en la tasa de recaída fue estadísticamente significativo (p=0,009).

Conclusiones:

La administración de la vacuna meningocócica C conjugada (VCMC) se asoció con un aumento significativo en la tasa de recaída del síndrome nefrótico en niños.
La decisión de vacunar a los niños con síndrome nefrótico con MCCV requiere una cuidadosa consideración debido a este efecto observado.

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