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Amyloide sérico a en la apnea obstructiva del sueño.
Anna Svatikova1, Robert Wolk, Abu S Shamsuzzaman
1Mayo Foundation, Rochester, Minn, USA
Circulation
|September 4, 2003
Resumen
Los pacientes con apnea obstructiva del sueño (AOS) de moderada a grave tienen niveles séricos significativamente más altos de proteína amiloide A (SAA). Estos niveles elevados de AAS pueden aumentar el riesgo de enfermedades cardiovasculares y cerebrovasculares en pacientes con AOS.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Medicina del sueño Medicina del sueño.
- La bioquímica es la bioquímica.
Sus antecedentes:
- La apnea obstructiva del sueño (AOS) se asocia con un mayor riesgo de enfermedad cardiovascular y cerebrovascular.
- La proteína amiloide sérica A (SAA) está implicada en la aterosclerosis, el accidente cerebrovascular, la diabetes y la demencia.
- La relación entre los niveles de SAA y OSA requiere más investigación.
Objetivo del estudio:
- Para probar la hipótesis de que los niveles plasmáticos de AAS están elevados en individuos sanos con AOS.
- Para comparar los niveles de AAS en pacientes con AOS moderada a grave, AOS leve y controles sanos.
- Para explorar la correlación entre los niveles de AAS y la gravedad de la AOS.
Principales métodos:
- Los niveles plasmáticos de SAA se midieron en pacientes masculinos y femeninos con AOS moderada a grave, AOS leve y controles emparejados.
- Las mediciones se tomaron antes del sueño, después de 5 horas de AOS no tratada y por la mañana después del tratamiento continuo de presión positiva en las vías respiratorias (CPAP).
- Se utilizó el índice de apnea-hipopnea (AHI) para evaluar la gravedad de la AOS.
Principales resultados:
- Los niveles basales plasmáticos de AAS fueron significativamente más altos en pacientes con AOS moderada a grave en comparación con los controles (18,8 frente a 7,2 microg / ml, P = 0,005).
- Los niveles de AAS en pacientes con AOS leve fueron comparables a los controles (P=0,46).
- Se observaron niveles elevados de AAS en OSA de moderada a severa tanto en hombres como en mujeres y se correlacionaron positivamente con el AHI (r=0.40, P=0.03).
Conclusiones:
- Los niveles plasmáticos de AAS son más del doble en pacientes con AOS moderada a grave, independientemente del género.
- El aumento de la AAS puede contribuir al aumento del riesgo de disfunción cardiovascular y neuronal en pacientes con AOS.
- Estos hallazgos destacan la AAS como un biomarcador potencial para las complicaciones relacionadas con la AOS.
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