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La oleiletanolamida regula la alimentación y el peso corporal a través de la activación del receptor nuclear
Jin Fu1, Silvana Gaetani, Fariba Oveisi
1Department of Pharmacology, University of California, Irvine, California 92697-4625, USA.
Nature
|September 5, 2003
Resumen
La Oleoylethanolamide (OEA) regula la saciedad y el peso corporal mediante la activación del receptor PPAR-alfa. Este hallazgo revela un nuevo papel para el PPAR-alfa en el comportamiento y ofrece tratamientos potenciales para los trastornos alimentarios.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- El metabolismo es el metabolismo.
- La neurociencia es la neurociencia.
Sus antecedentes:
- La Oleoylethanolamide (OEA) es un lípido involucrado en la regulación de la saciedad y el peso corporal.
- Los objetivos moleculares y el mecanismo de acción de la OEA no se comprenden completamente.
- La OEA es estructuralmente similar a la anandamida, pero no se une a los receptores cannabinoides.
Objetivo del estudio:
- Para identificar los objetivos moleculares de la OEA.
- Para aclarar el mecanismo por el cual la OEA regula la saciedad y el peso corporal.
- Explorar el potencial terapéutico de la OEA para los trastornos de la alimentación.
Principales métodos:
- Ensayos vinculantes para identificar los objetivos moleculares de la OEA.
- Administración de OEA a ratones de tipo salvaje y con deficiencia de PPAR-alfa.
- Análisis de la expresión génica en el intestino delgado de ratones.
- Prueba de los efectos de los agonistas de PPAR-alfa.
Principales resultados:
- La OEA se une con una alta afinidad al receptor alfa activado por el proliferador de peroxisomas (PPAR-alfa).
- La administración de OEA reduce el aumento de peso corporal e induce la saciedad en ratones de tipo salvaje, pero no en ratones con deficiencia de PPAR-alfa.
- La OEA regula los genes diana de PPAR-alfa en el intestino delgado, afectando el metabolismo de los lípidos y la óxido nítrico sintasa.
- Los agonistas de PPAR-alfa imitan los efectos del OEA, mientras que los agonistas de PPAR-gamma y PPAR-beta/delta no lo hacen.
Conclusiones:
- La OEA ejerce sus efectos sobre la saciedad y el peso corporal mediante la activación de PPAR-alfa.
- PPAR-alfa juega un papel no reconocido previamente en la regulación del comportamiento de alimentación.
- La OEA y la activación de PPAR-alfa representan estrategias terapéuticas potenciales para el manejo de los trastornos de la alimentación y la obesidad.
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