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Mostramiento constitutivo de los productos de traducción críptica por moléculas de clase I de MHC

Susan R Schwab1, Katy C Li, Chulho Kang

  • 1Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.

Science (New York, N.Y.)
|September 6, 2003
PubMed
Resumen

Las moléculas del complejo mayor de histocompatibilidad (MHC) clase I presentan péptidos raros de regiones 3' no traducidas, desencadenando respuestas inmunes y auto-tolerancia. Esto revela un nuevo mecanismo de traducción que utiliza codones de iniciación CUG no canónicos.

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