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Aislamiento y caracterización de virus relacionados con el coronavirus SARS de animales en el sur de China
1Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China. yguan@hkucc.hku.hk
Science (New York, N.Y.)
|September 6, 2003
Resumen
Un nuevo coronavirus que causa el síndrome respiratorio agudo severo (SARS) se encontró en civetas y otros animales en un mercado chino. Esto sugiere una vía para la transmisión de virus entre especies a los humanos.
Área de la Ciencia:
- Virología Virología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Epidemiología La epidemiología.
Sus antecedentes:
- Un nuevo coronavirus (SCoV) causa el síndrome respiratorio agudo severo (SARS).
- Los mercados de animales vivos son centros potenciales para la aparición de enfermedades zoonóticas.
- Comprender los orígenes del SARS es fundamental para la salud pública.
Objetivo del estudio:
- Para identificar la fuente y las rutas de transmisión del nuevo coronavirus responsable del SARS.
- Para investigar la presencia de virus similares al SCoV en poblaciones de animales dentro de un mercado de animales vivos.
Principales métodos:
- Aislamiento e identificación del virus a partir de muestras de animales y humanos.
- Secuenciación genética para comparar aislamientos virales.
- Investigación epidemiológica dentro del entorno de mercado.
Principales resultados:
- Los virus similares al SCoV fueron aislados de civetas de palma del Himalaya, perros mapache y humanos en un mercado de Guangdong.
- Los aislamientos animales contenían una secuencia única de 29 nucleótidos ausente en la mayoría de los aislamientos humanos.
- La evidencia indicó la circulación del virus entre animales y humanos en el mercado.
Conclusiones:
- Los mercados de mamíferos salvajes vivos facilitan la transmisión entre especies del SCoV.
- Las civetas y potencialmente otros mamíferos son reservorios o huéspedes intermedios para el SARS-CoV.
- El reservorio natural del SARS-CoV sigue siendo indeterminado, lo que requiere más investigación.
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