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Producción sensible al litio de fosfatos de inositol durante la inducción del mesodermo embrionario anfibio

J A Maslanski¹, L Leshko, W B Busa

¹Department of Biology, Johns Hopkins University, Baltimore, MD 21218.

Science (New York, N.Y.)

|April 10, 1992

Resumen

Los iones de litio (Li+) interrumpen el desarrollo del embrión de la rana al inhibir el ciclo de polifosfoinositida (PI). Esta vía es crucial para la inducción del mesodermo y la determinación del eje corporal, lo que sugiere que la actividad del ciclo PI es esencial para el desarrollo embrionario temprano.

Área de la Ciencia:

Biología del desarrollo Biología del desarrollo.
La señalización celular de las células.
La bioquímica es la bioquímica.

Sus antecedentes:

La inducción del mesodermo y la determinación del eje corporal en los embriones de Xenopus son procesos críticos de desarrollo.
Se cree que estos procesos implican la señalización célula-célula mediada por el factor de crecimiento.
Las vías específicas de transducción de señales siguen siendo en gran medida desconocidas.

Objetivo del estudio:

Investigar el papel del ciclo de polifosfoinositida (PI) en el desarrollo embrionario de Xenopus.
Para determinar si el ciclo PI está involucrado en la inducción del mesodermo y la determinación del eje del cuerpo.

Principales métodos:

Utilizado iones de litio (Li +) como un inhibidor del ciclo PI.
Los niveles medidos de inositol 1,4,5-trisfosfato, un segundo mensajero en el ciclo de PI.
Se evaluó el impacto de Li+ en la actividad embrionaria de la inositol monofosfatasa.

Principales resultados:

Se encontró que los iones de litio (Li +) interrumpen la determinación del eje y la inducción del mesodermo en embriones de Xenopus.
Los niveles de inositol 1,4,5-trisfosfato aumentaron durante la inducción normal del mesodermo.
Li+ inhibió la inositol monofosfatasa embrionaria, revirtiendo el aumento en el inositol 1,4,5-trisfosfato.

Conclusiones:

La actividad del ciclo PI embrionario está implicada en la inducción del mesodermo y la determinación del eje corporal en Xenopus.
El ciclo PI representa una vía potencial de transducción de señales involucrada en estos eventos fundamentales del desarrollo.

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