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Interacciones simpáticas e inmunes durante el ejercicio dinámico. La mediación a través de un mecanismo dependiente
D R Murray1, M Irwin, C A Rearden
1Department of Medicine, University of California San Diego.
Circulation
|July 1, 1992
Resumen
El ejercicio agudo moviliza las células inmunes a través de los receptores beta-2, influyendo en la función inmune. El propranolol bloquea estos efectos, mientras que el metoprolol no lo hace, lo que indica una interacción entre el sistema nervioso simpático y el sistema inmunológico mediada por beta 2.
Área de la Ciencia:
- Inmunología Inmunología.
- La neurociencia es la neurociencia.
- Fisiología del ejercicio Fisiología del ejercicio
Sus antecedentes:
- La interacción entre el sistema nervioso simpático y la función inmune no se entiende completamente.
- Estudios previos sugieren que las catecolaminas influyen en la circulación de los linfocitos a través de los receptores beta-2.
Objetivo del estudio:
- Investigar si la estimulación simpática aguda afecta el tráfico y la función de las células inmunes a través de los receptores beta 2.
- Para determinar el papel de los receptores beta 2-adrenérgicos en las respuestas inmunes inducidas por el ejercicio.
Principales métodos:
- Voluntarios sanos se sometieron a un ejercicio exhaustivo (protocolo Bruce) antes y después del tratamiento con beta-bloqueantes (propranolol o metoprolol).
- Se midieron los subconjuntos de linfocitos circulantes (Ts / c, NK, T helper, células B) y las funciones inmunes (expresión del receptor IL-2, proliferación, actividad de NK).
- Se compararon los efectos del antagonista beta no selectivo propranolol y el antagonista beta 1 selectivo metoprolol en los cambios inducidos por el ejercicio.
Principales resultados:
- El ejercicio exhaustivo indujo una linfocitosis marcada, particularmente en las células supresoras de T / citotóxicas (Ts / c) y asesinas naturales (NK).
- El ejercicio alteró la función inmune, disminuyendo la expresión y la proliferación de los receptores de IL-2 mientras aumentaba la actividad de las células NK.
- El tratamiento con propranolol redujo los aumentos inducidos por el ejercicio en las células Ts / c y NK y las alteraciones de la función inmune.
- El tratamiento con metoprolol no afectó a los cambios inducidos por el ejercicio en los parámetros inmunológicos.
Conclusiones:
- La estimulación simpática aguda a través del ejercicio libera selectivamente las células inmunorreguladoras.
- Estos cambios inmunológicos inducidos por el ejercicio están mediados por receptores beta 2-adrenérgicos.
- La atenuación de estos efectos por el propranolol, a diferencia del metoprolol, apoya un mecanismo mediado por beta 2 en las interacciones simpático-inmunes.
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