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El TNF activa el NF-kappa B por la descomposición de la esfingomielina "ácida" inducida por la fosfolipasa C,

S Schütze1, K Potthoff, T Machleidt

  • 1Institut für Medizinische Mikrobiologie und Hygiene, Technische Universität München, Germany.

Cell
|November 27, 1992
PubMed
Resumen

El factor de necrosis tumoral (TNF) activa el factor de transcripción NF-kappa B a través de una vía fosfolípida. Esto implica la descomposición de la esfingomielina a ceramida, desencadenada por una esfingomielinasa ácida, que en última instancia induce la actividad de NF-kappa B.

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