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Estudio multicéntrico de la gestrinona en el dolor mamario cíclico
1Department of Obstetrics and Gynecology, St Hildegardis Hospital, Johannes Gutenberg University, Mainz, Germany.
Lancet (London, England)
|January 25, 1992
Resumen
La gestrinona redujo significativamente el dolor y los síntomas de la mastalgia cíclica mamaria en comparación con el placebo. Este estudio encontró que la gestrinona es efectiva y bien tolerada para controlar el dolor cíclico de mama.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Ginecología Ginecología.
- Farmacología Farmacología.
Sus antecedentes:
- La etiología de la mastalgia cíclica es poco conocida.
- El aumento de la respuesta a la estimulación de la prolactina posiblemente debido a la dominación del estrógeno es un hallazgo consistente.
- Los medicamentos que reducen la prolactina y los antiestrógenos se utilizan como tratamientos.
Objetivo del estudio:
- Investigar la eficacia y seguridad de la gestrinona en el tratamiento de la mastalgia cíclica.
- La gestrinona posee propiedades androgénicas, antiestrógenas y antiprogestagenas.
Principales métodos:
- Un estudio multicéntrico, doble ciego y aleatorizado.
- 73 pacientes recibieron gestrinona (2,5 mg dos veces por semana) y 72 recibieron placebo durante 3 meses.
- El dolor de mama y los síntomas fueron calificados utilizando una escala analógica visual y una escala 0-3, respectivamente.
Principales resultados:
- El grupo de gestrinona mostró reducciones significativamente mayores en las puntuaciones de dolor mamario a los 1, 2 y 3 meses (p < 0,0001).
- Los seis síntomas mamarios mejoraron significativamente en el grupo de gestrinona al final del estudio.
- El tratamiento con gestrinona redujo el estradiol sérico, la progesterona y la tri-iodotironina, pero no afectó a otras hormonas.
Conclusiones:
- La gestrinona es altamente efectiva para el tratamiento de la mastalgia cíclica.
- La gestrinona fue bien tolerada, y la mayoría de los efectos secundarios fueron mediados por andrógenos.
- Menos pacientes interrumpieron el tratamiento en el grupo de gestrinona en comparación con el placebo.
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