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El sulfato de dermatanos en la hemodiálisis
1Department of Haematology, Charing Cross and Westminster Hospital and Medical School, London, UK.
Lancet (London, England)
|February 8, 1992
Resumen
El sulfato de dermatan inhibe eficazmente los coágulos sanguíneos en pacientes sometidos a hemodiálisis. Este agente antitrombótico se muestra prometedor como una alternativa más segura a la heparina para prevenir la trombosis.
Área de la Ciencia:
- Farmacología Farmacología.
- Hematología Hematología.
- Nefrología Nefrología.
Sus antecedentes:
- El sulfato de dermatano exhibe propiedades antitrombóticas, inhibiendo potencialmente la trombosis venosa con menos riesgo de sangrado que la heparina.
- A diferencia de la heparina, que se dirige a la antitrombina III, el sulfato de dermatan inhibe selectivamente la trombina a través del cofactor II de la heparina.
Objetivo del estudio:
- Evaluar la eficacia y seguridad del sulfato de dermatan como agente anticoagulante y antitrombótico.
- Para llevar a cabo estudios de determinación de dosis para el sulfato de dermatan en pacientes que requieren hemodiálisis de mantenimiento.
Principales métodos:
- Se realizaron estudios de determinación de la dosis.
- La población del estudio estaba compuesta por pacientes en hemodiálisis de mantenimiento.
Principales resultados:
- El sulfato de dermatano demostró eficacia como anticoagulante en el grupo de pacientes estudiado.
- El agente mostró potencial para la actividad antitrombótica.
Conclusiones:
- El sulfato de dermatan es un anticoagulante eficaz en pacientes sometidos a hemodiálisis de mantenimiento.
- Se requiere una mayor investigación sobre el potencial antitrombótico del sulfato de dermatan.
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