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Alta inmunorreactividad de la endotelina-1 en la enfermedad de Crohn y la colitis ulcerosa
S H Murch1, C P Braegger, W C Sessa
1Department of Paediatric Gastroenterology, St Bartholomew's Hospital Medical College, London, UK.
Lancet (London, England)
|February 15, 1992
Resumen
Las enfermedades inflamatorias intestinales como la enfermedad de Crohn y la colitis ulcerosa muestran un aumento de la producción de endotelina-1. Este vasoconstrictor puede causar isquemia intestinal y vasculitis en pacientes con estas afecciones crónicas.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Inmunología Inmunología.
- Biología Vascular Biología Vascular
Sus antecedentes:
- La patogénesis de la enfermedad inflamatoria intestinal (EII) implica hipersensibilidad inmune y problemas vasculares.
- La endotelina-1, un potente vasoconstrictor, es un vínculo potencial entre estas hipótesis.
Objetivo del estudio:
- Para investigar la producción local de endotelina-1 en pacientes con enfermedad de Crohn (EC) y colitis ulcerosa (UC).
- Para determinar si la endotelina-1 contribuye a las anomalías vasculares en la EII.
Principales métodos:
- Inmunohistoquímica para detectar endotelina-1 en muestras de tejido de 16 pacientes con CD, 9 pacientes con UC y 13 controles.
- Radioinmunoensayo para medir las concentraciones de endotelina en supernatantes de tejidos homogeneizados.
Principales resultados:
- Celdas inmunorreactivas de endotelina-1 significativamente más altas en los tejidos de CD y UC en comparación con los controles.
- Patrones de distribución distintos de las células de endotelina-1 en CD (submucosa > lámina propia) y UC (lamina propia > submucosa).
- Concentraciones elevadas de endotelina en los tejidos de CD y UC.
Conclusiones:
- La producción local de endotelina-1 por las células inflamatorias se incrementa en la EII.
- La endotelina-1 puede contribuir a la vasculitis asociada a la EII y a la isquemia intestinal a través de la vasoconstricción.
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