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Alta incidencia de linfoma gástrico primario en el noreste de Italia
C Doglioni1, A C Wotherspoon, A Moschini
1Ospedale Civile, Feltre, Italy.
Lancet (London, England)
|April 4, 1992
Resumen
La incidencia de linfoma gástrico primario (PGL) es 13 veces mayor en Feltre, Italia, en comparación con las comunidades del Reino Unido. Este estudio investigó las tasas de PGL y cáncer gástrico, vinculándolas a la prevalencia de la infección por Helicobacter pylori.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Oncología Oncología.
- Epidemiología La epidemiología.
Sus antecedentes:
- Anteriormente se había observado una incidencia inusualmente alta de linfoma gástrico primario (LGP) en el noreste de Italia.
- Los cánceres e infecciones gástricas plantean importantes desafíos para la salud mundial.
Objetivo del estudio:
- Comparar formalmente la incidencia de GLP en Feltre, Italia, con comunidades similares en el Reino Unido.
- Investigar la incidencia del adenocarcinoma gástrico y la prevalencia de la infección por Helicobacter pylori en las mismas regiones.
Principales métodos:
- Diseño del estudio epidemiológico comparativo.
- Análisis de la GPL y de los datos de incidencia de adenocarcinoma gástrico de 1986-1991.
- Evaluación de la prevalencia de la infección por Helicobacter pylori en muestras de biopsia gástrica desde 1991.
Principales resultados:
- Feltre, Italia, exhibió 13 veces más casos de PGL que las comunidades del Reino Unido (66 frente a 5 por cada 100,000 durante 5 años).
- La incidencia de adenocarcinoma gástrico fue sustancialmente mayor en Feltre (270 frente a 82 por cada 100.000 durante 5 años).
- La prevalencia de gastritis asociada con la infección por H. pylori fue alta en Feltre (87% de las muestras).
Conclusiones:
- La incidencia de linfoma gástrico primario y adenocarcinoma gástrico es significativamente elevada en Feltre, Italia.
- Las altas tasas de infección por Helicobacter pylori pueden contribuir al aumento de la patología gástrica observada en Feltre.
- Se necesita más investigación para dilucidar los factores etiológicos detrás de estas disparidades geográficas.
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