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Efectos del aumento de las concentraciones de oxígeno inspirado en el rendimiento del ejercicio en la insuficiencia
D P Moore1, A R Weston, J M Hughes
1Division of Clinical Cardiology, Royal Postgraduate Medical School, London, UK.
Lancet (London, England)
|April 4, 1992
Resumen
El oxígeno suplementario mejora la capacidad de ejercicio en pacientes con insuficiencia cardíaca. Los niveles más altos de oxígeno mejoran la duración del ejercicio y reducen la falta de aliento y la fatiga, lo que sugiere posibles beneficios terapéuticos.
Área de la Ciencia:
- Cardiología Cardiología.
- Medicina Pulmonar La medicina pulmonar es el tratamiento de las enfermedades pulmonares.
- Fisiología del ejercicio Fisiología del ejercicio
Sus antecedentes:
- Los pacientes con insuficiencia cardíaca crónica (ICC) experimentan una capacidad de ejercicio limitada.
- Las intervenciones agudas generalmente se consideran ineficaces para mejorar la tolerancia al ejercicio en la insuficiencia cardíaca congestiva.
Objetivo del estudio:
- Para investigar los efectos agudos de las diferentes concentraciones de oxígeno inspirado en las respuestas cardiorrespiratorias durante el ejercicio en pacientes con insuficiencia cardíaca estable.
- Determinar si el oxígeno suplementario puede mejorar agudamente el rendimiento del ejercicio y modificar las respuestas fisiológicas en la insuficiencia cardíaca congestiva.
Principales métodos:
- 12 pacientes con insuficiencia cardíaca congestiva crónica se sometieron en serie a pruebas de ejercicio submáximo y máximo.
- Las pruebas se llevaron a cabo con concentraciones de oxígeno inspirado del 21% (aire ambiente), 30% y 50%.
Principales resultados:
- La duración media del ejercicio aumentó significativamente de 548s con aire ambiente a 632s con oxígeno al 50% (p=0,012).
- A 45W de ejercicio en estado estacionario, el 50% de oxígeno aumentó la saturación arterial de oxígeno y redujo la ventilación por minuto, el rendimiento cardíaco, la fatiga y la falta de aliento.
- El 30% de oxígeno mostró efectos intermedios.
Conclusiones:
- El aumento de las concentraciones de oxígeno inspirado puede mejorar agudamente el rendimiento del ejercicio en pacientes con insuficiencia cardíaca.
- La hiperoxia modifica las respuestas ventilatorias y reduce la demanda circulatoria mientras se mantiene el suministro de oxígeno.
- El potencial del oxígeno inspirado elevado en el manejo de la insuficiencia cardíaca crónica merece una mayor investigación.
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