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Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
Validez de los métodos utilizados para evaluar la capacidad de respuesta de las vías respiratorias en niños
1Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Western Australia.
Lancet (London, England)
|May 23, 1992
Resumen
La dosificación de los agonistas inhalados en niños puede no ser corregida por el tamaño, lo que podría sesgar los resultados. Las pruebas actuales de respuesta de las vías respiratorias en poblaciones pediátricas deben considerarse cualitativas hasta que las dosis se ajusten adecuadamente al tamaño corporal.
Área de la Ciencia:
- Pulmonología Pediátrica.
- Fisiología de las vías respiratorias.
Sus antecedentes:
- Los métodos de prueba de la capacidad de respuesta de las vías respiratorias se adaptaron a los protocolos de adultos.
- Los regímenes de dosis actuales de agonistas no tienen en cuenta las variaciones de tamaño corporal pediátrico.
Objetivo del estudio:
- Evaluar el impacto de las dosis no corregidas de agonistas en las mediciones de respuesta de las vías respiratorias en niños.
- Para determinar si las disminuciones de respuesta relacionadas con la edad son artefactos de la dosificación.
Principales métodos:
- Revisión de las metodologías existentes para probar la capacidad de respuesta de las vías respiratorias en niños.
- Análisis de los cálculos de la dosis del agonista en relación con el tamaño corporal en estudios pediátricos.
Principales resultados:
- Los niños pequeños reciben dosis de agonista desproporcionadamente más altas en comparación con los niños más grandes.
- Esta discrepancia de tamaño puede conducir a una mala interpretación de los datos de respuesta de las vías respiratorias.
Conclusiones:
- Las disminuciones observadas relacionadas con la edad en la capacidad de respuesta de las vías respiratorias pueden ser un artefacto de una inadecuada corrección de tamaño.
- Las pruebas de respuesta de las vías respiratorias pediátricas deben interpretarse como cualitativas hasta que las dosis de agonistas sean adecuadamente ajustadas.
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