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Adenilato ciclasa sensible a la dopamina: ubicación en la sustancia negra
Science (New York, N.Y.)
|February 4, 1977
Resumen
Los receptores de dopamina en la sustancia negra de la rata no están en las células de dopamina. En cambio, se encuentran en vías que se proyectan desde el cerebro anterior, involucrando GABA o sustancia P.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La neuroquímica es la neuroquímica.
Sus antecedentes:
- La adenilato ciclasa sensible a la dopamina existe en la sustancia negra de la rata.
- Sus características se asemejan a las encontradas en el estriado.
Objetivo del estudio:
- Para determinar la ubicación de los receptores de dopamina en la sustancia negra.
- Investigar si estos receptores se encuentran en los cuerpos celulares de la dopamina o en vías asociadas.
Principales métodos:
- Estudios de lesiones en ratas.
- Aplicación intranigral de 6-hidroxidopamina para destruir los cuerpos celulares de la dopamina.
- Hemitransección cerebral y lesiones circunscritas de las vías estriatonigrales.
Principales resultados:
- La destrucción de los cuerpos celulares de dopamina no abolió el efecto de la dopamina en la adenilato ciclasa nigral.
- La lesión de las vías estriatonigrales abolió la estimulación de la dopamina de la adenilato ciclasa en la sustancia negra.
Conclusiones:
- Los receptores de dopamina en la sustancia negra no se encuentran en los cuerpos celulares de la dopamina.
- Estos receptores están asociados con vías aferentes, potencialmente involucrando GABA o sustancia P, que se proyectan desde el cerebro anterior.
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