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Infección diseminada por "Mycobacterium genavense" en pacientes con SIDA
E C Böttger1, A Teske, P Kirschner
1Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Germany.
Lancet (London, England)
|July 11, 1992
Resumen
Una nueva especie de Mycobacterium, Mycobacterium genavense, causó una infección diseminada en 18 pacientes con VIH avanzado. Esta bacteria debe considerarse en individuos inmunocomprometidos con fiebre inexplicable y pérdida de peso.
Área de la Ciencia:
- Microbiología Microbiología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Inmunología Inmunología.
Sus antecedentes:
- La infección avanzada por VIH a menudo se presenta con infecciones oportunistas.
- El síndrome de desgaste y la fiebre crónica son comunes en individuos con inmunodeficiencia severa.
Objetivo del estudio:
- Identificar el agente causante de la infección diseminada en una cohorte de pacientes con VIH avanzado.
- Para caracterizar un nuevo microorganismo encontrado en múltiples tejidos de individuos afectados.
- Proponer una nueva especie dentro del género Mycobacterium.
Principales métodos:
- Análisis de muestras de biopsia y necropsia de 18 pacientes con VIH avanzado.
- Examen microscópico para la detección de microorganismos ácidos.
- Intentos de cultivo bacteriano en medios sólidos y líquidos.
- Amplificación del ADN y secuenciación del ARNr 16S bacteriano de varios tejidos y cultivos de sangre.
Principales resultados:
- Se detectaron abundantes microorganismos ácido-rápidos en múltiples órganos.
- El microorganismo mostró un crecimiento limitado en cultivos líquidos, pero no en medios sólidos.
- Se obtuvieron secuencias únicas de ADN, lo que indica una nueva especie bacteriana.
- El microorganismo fue identificado como un nuevo miembro del género Mycobacterium, llamado Mycobacterium genavense.
Conclusiones:
- Mycobacterium genavense es un patógeno recientemente identificado responsable de las infecciones diseminadas.
- Esta infección debe considerarse en el diagnóstico diferencial de pacientes infectados por el VIH gravemente inmunocomprometidos con mareos y fiebre.
- Se necesita más investigación para comprender la patogénesis y el tratamiento de las infecciones por M. genavense.
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