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Baja dosis de aspirina y posterior cirugía arterial periférica en el Estudio de Salud de los Médicos
S Z Goldhaber1, J E Manson, M J Stampfer
1Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Lancet (London, England)
|July 18, 1992
Resumen
La dosis baja de aspirina redujo significativamente la necesidad de cirugía arterial periférica en hombres sanos. Este hallazgo sugiere aspirina.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Cardiología Preventiva y Cardiología Preventiva.
- Los ensayos clínicos son ensayos clínicos.
Sus antecedentes:
- La enfermedad arterial periférica (EAP) es una condición vascular significativa.
- La cirugía arterial periférica es una intervención común para la EAP avanzada.
- El papel de la aspirina en dosis bajas en la prevención de las complicaciones de la EAP requiere más investigación.
Objetivo del estudio:
- Para investigar el efecto de la dosis baja de aspirina en la incidencia de cirugía arterial periférica.
- Para probar la hipótesis de que el uso de aspirina puede reducir la necesidad de cirugía vascular.
Principales métodos:
- Se empleó un diseño de ensayo aleatorizado, doble ciego, controlado con placebo.
- En el estudio participaron 22.071 médicos estadounidenses sanos de entre 40 y 84 años.
- Los participantes recibieron una dosis baja de aspirina (325 mg en días alternos) o un placebo.
Principales resultados:
- Un total de 56 participantes se sometieron a cirugía arterial periférica (20 en el grupo de aspirina, 36 en el grupo de placebo).
- El riesgo relativo de cirugía de la arteria periférica fue significativamente menor en el grupo de aspirina (0,54; IC del 95%: 0,30-0,95; p = 0,03).
Conclusiones:
- La administración crónica de dosis bajas de aspirina se asoció con una menor necesidad de cirugía arterial periférica en hombres aparentemente sanos.
- Estos hallazgos apoyan el potencial papel preventivo de la aspirina en la reducción de las principales intervenciones vasculares para la enfermedad arterial periférica.
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