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Ligandos endógenos del receptor de benzodiazepinas en el estupor idiopático recurrente recurrente
J D Rothstein1, A Guidotti, P Tinuper
1Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205.
Lancet (London, England)
|October 24, 1992
Resumen
El estupor recurrente idiopático (IRS) implica un coma espontáneo revertido por el flumazenil. Los investigadores encontraron niveles significativamente elevados de endozepina-4 durante los episodios de IRS, lo que sugiere que puede causar este trastorno neurológico.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La bioquímica es la bioquímica.
Sus antecedentes:
- Las endozepinas son ligandos endógenos para los receptores GABA-A.
- El estupor recurrente idiopático (IRS) es un trastorno neurológico caracterizado por estupor o coma espontáneo.
- Los episodios de IRS son reversibles con el flumazenil, un antagonista de las benzodiazepinas.
Objetivo del estudio:
- Para investigar el papel de las endozepinas en el estupor idiopático recurrente (IRS).
- Para medir los niveles de endozepina-2 y endozepina-4 en pacientes con IRS.
Principales métodos:
- Se utilizaron cromatografía líquida de alto rendimiento (HPLC) y ensayo de radiorreceptores.
- Se recogieron muestras de suero y líquido cefalorraquídeo (LCR) de tres pacientes del IRS.
- Las mediciones se tomaron durante los episodios de estupor y entre los ataques.
Principales resultados:
- Se observó un aumento significativo (hasta 300 veces) en los niveles de endozepina-4 tanto en el suero como en el LCR durante los episodios de IRS.
- Los niveles de endozepina-4 volvieron a las concentraciones normales entre los episodios.
- Los niveles de endozepina-2 no se especificaron en el resumen.
Conclusiones:
- La endozepina-4 puede desempeñar un papel causal en el estupor idiopático recurrente.
- Las razones subyacentes de las concentraciones anormales de endozepina en el IRS siguen siendo desconocidas.
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