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Updated: Jun 29, 2026

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Las mutaciones en los genes de receptores de antígenos de células T alfa y beta bloquean el desarrollo de timocitos

P Mombaerts1, A R Clarke, M A Rudnicki

  • 1Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts.

Nature
|November 19, 1992
PubMed
Resumen

La reorganización del gen beta del receptor de células T (TCR) es esencial para el desarrollo y la expansión de los timocitos CD4 + CD8 +. TCR-alfa y TCR-beta no son necesarios para el desarrollo de las células gamma delta T, lo que indica vías de desarrollo distintas.

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