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Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging
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Selección de conexiones horizontales intrínsecas en la corteza visual por la actividad neuronal correlacionada
1Max-Planck-Institut für Hirnforschung, Frankfurt am Main, Federal Republic of Germany.
Science (New York, N.Y.)
|January 10, 1992
Resumen
La experiencia visual da forma a los circuitos cerebrales. En gatitos con estrabismo, las conexiones de la corteza visual favorecieron a las células con actividad correlacionada, lo que demuestra una selección de circuitos dependiente de la experiencia.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Neurociencia del desarrollo neurológico.
- El sistema visual del sistema visual.
Sus antecedentes:
- Colaterales de axones de largo alcance en la corteza visual conectan grupos celulares.
- Estas conexiones se refinan después del parto a través de la poda.
- El papel de la actividad neuronal correlacionada en la especificidad del circuito no está claro.
Objetivo del estudio:
- Investigar si la actividad neuronal correlacionada guía la estabilización selectiva de las conexiones en la corteza visual.
- Para determinar el impacto de la experiencia visual en el desarrollo de los circuitos intracorticales.
Principales métodos:
- Los gatitos fueron criados con estrabismo inducido para interrumpir la correlación de la señal interocular.
- Se analizaron la actividad neuronal y los patrones de conexión en el área 17.
Principales resultados:
- Los grupos celulares en el área 17 fueron impulsados predominantemente por la entrada de un solo ojo.
- Las fibras intracorticales tangenciales unen preferentemente grupos celulares activados por el mismo ojo.
Conclusiones:
- El desarrollo del circuito visual depende de la experiencia visual.
- La correlación de la actividad neuronal sirve como criterio de selección crítico para las conexiones sinápticas.
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