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Hiperalgesia mediada por el glutamato espinal o el receptor de sustancia P bloqueado por la inhibición de la

A B Malmberg¹, T L Yaksh

¹Department of Anesthesiology, University of California-San Diego, La Jolla 92093-0818.

Science (New York, N.Y.)

|August 28, 1992

Resumen

Los antiinflamatorios no esteroideos (AINE) proporcionan alivio del dolor a través de acciones espinales directas, no sólo efectos antiinflamatorios periféricos. Este mecanismo espinal se dirige a la sensibilidad excesiva al dolor mediante el bloqueo de los receptores clave.

Área de la Ciencia:

Farmacología Farmacología.
La neurociencia es la neurociencia.
Investigación del dolor Investigación del dolor.

Sus antecedentes:

Los antiinflamatorios no esteroideos (AINE) son ampliamente utilizados para el alivio del dolor (analgesia).
Su mecanismo primario se considera típicamente la inhibición periférica de la ciclooxigenasa.
El papel de los mecanismos espinales en la analgesia de los AINE requiere una mayor aclaración.

Objetivo del estudio:

Para investigar las acciones espinales directas de los AINE en la modulación del dolor.
Para determinar si los AINE pueden atenuar selectivamente la hiperalgesia espinal.
Para explorar la disociación entre los efectos analgésicos y antiinflamatorios de los AINE.

Principales métodos:

Administración de AINE para dirigirse a las vías espinales.
Evaluación de la sensibilidad al dolor (hiperalgesia) después de la activación del receptor.
Análisis del papel de los receptores espinales del glutamato y de la sustancia P.

Principales resultados:

Los AINE ejercen una acción directa a nivel de la columna vertebral.
Esta acción espinal bloquea efectivamente la hiperalgesia inducida por el glutamato y la sustancia P.
La analgesia inducida por los AINE puede separarse de sus acciones antiinflamatorias periféricas.

Conclusiones:

Los AINE poseen un mecanismo analgésico espinal directo.
Los prostanoides espinales son cruciales para el procesamiento de señales de dolor amplificadas.
Esto pone de relieve una vía espinal distinta para el alivio del dolor mediado por AINE.

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