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La susceptibilidad genética a la esclerosis múltiple está relacionada con el gen de la proteína básica de mielina

P J Tienari1, J Wikström, A Sajantila

  • 1Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland.

Lancet (London, England)
|October 24, 1992
PubMed
Resumen

La predisposición genética a la esclerosis múltiple (EM) está relacionada con el gen de la proteína básica de mielina (MBP). Los polimorfismos en el gen MBP pueden desempeñar un papel en la etiología de la EM, particularmente en las poblaciones finlandesas.

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Chromosomal Alterations Are Large-Scale Mutations
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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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