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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Life Tables01:22

Life Tables

A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
Applications of Life Tables01:22

Applications of Life Tables

Life tables are versatile across various fields, providing a quantitative basis for analyzing mortality and survival rates. Whether used by demographers, actuaries, epidemiologists, or sociologists, life tables offer valuable insights into the dynamics of life and death, facilitating informed decisions in public health, insurance, conservation, and beyond. Their broad applicability highlights the interconnectedness of demographic data with practical outcomes in everyday life and strategic...
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Temperature-Dependent Growth of Brook TroutThe growth of brook trout is closely influenced by water temperature. Experimental data demonstrate how trout weight changes over a 24-day period in response to varying water temperatures. At lower temperatures, such as 15.5 degrees Celsius, brook trout show significant weight gain. However, as the temperature increases, the amount of weight gained steadily decreases. At the highest temperature measured, 24.4 degrees Celsius, trout experience a net...

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Video Experimental Relacionado

Updated: Jul 18, 2026

Measurement of Lifespan in Drosophila melanogaster
10:00

Measurement of Lifespan in Drosophila melanogaster

Published on: January 7, 2013

Cambio en el peso corporal y longevidad.

I M Lee1, R S Paffenbarger

  • 1Department of Epidemiology, Harvard University School of Public Health, Boston, Mass 02115.

JAMA
|October 31, 1992
PubMed
Resumen

Las fluctuaciones significativas en el peso corporal, tanto la pérdida como la ganancia, están relacionadas con un mayor riesgo de mortalidad. El mantenimiento de un peso estable se asocia con las tasas de mortalidad por todas las causas y enfermedades coronarias más bajas.

Área de la Ciencia:

  • Epidemiología La epidemiología.
  • Gerontología Gerontología.
  • Salud Pública La salud pública.

Sus antecedentes:

  • Las fluctuaciones del peso corporal son comunes, pero su impacto a largo plazo en los resultados de salud sigue siendo una preocupación significativa para la salud pública.
  • Comprender la relación entre el cambio de peso y la mortalidad es crucial para desarrollar intervenciones de salud efectivas.

Objetivo del estudio:

  • Investigar la asociación entre el cambio de peso corporal y la mortalidad por todas las causas, la enfermedad coronaria y el cáncer.
  • Para determinar si los ciclos de peso influyen en la longevidad.

Principales métodos:

  • Un estudio analítico de cohorte siguió a 11.703 ex alumnos de la Universidad de Harvard (edad media de 58) desde 1977 hasta 1988.
  • El cambio de peso se evaluó en base a los datos autoinformados de los cuestionarios administrados en 1962/1966 y 1977.

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  • Los datos de mortalidad (todas las causas, enfermedad coronaria, cáncer) se obtuvieron de los certificados de defunción.

    • Principales resultados:

    • La mortalidad por todas las causas más baja se observó en individuos con peso estable (+/- 1 kg).
    • Los aumentos significativos en la mortalidad por todas las causas y la enfermedad coronaria se asociaron tanto con una pérdida de peso sustancial (> 5 kg) como con un aumento de peso (> 5 kg).
    • El cambio de peso no predijo la mortalidad por cáncer, y los hallazgos fueron independientes del tabaquismo, la actividad física y el índice de masa corporal.

    Conclusiones:

    • Tanto la pérdida como la ganancia de peso corporal, tanto intencional como no intencional, se asocian con un aumento de la mortalidad por todas las causas y la enfermedad coronaria.
    • Los ciclos de peso pueden ser un factor que contribuye al aumento del riesgo de mortalidad.
    • Mantener un peso corporal estable parece ser óptimo para la longevidad.