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Updated: Jun 18, 2026

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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
Published on: October 7, 2016
Bloqueo cardíaco congénito completo. Aspectos del desarrollo Aspectos del desarrollo
Circulation
|July 1, 1977
Resumen
El bloqueo cardíaco completo congénito surge de trastornos en el sistema de conducción atrioventricular, con tipos distintos relacionados con el desarrollo embrionario del corazón.
Área de la Ciencia:
- Embriología cardiovascular Embriología cardiovascular
- Enfermedad cardíaca congénita.
- Electrofisiología Cardíaca Electrofisiología cardíaca.
Sus antecedentes:
- El bloqueo cardíaco completo congénito (CCHB) presenta un espectro de defectos de conducción atrioventricular.
- Comprender los orígenes del desarrollo de CCHB es crucial para una clasificación y gestión precisas.
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Overview of the Heart
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The heart's structure...
The heart's structure...
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Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
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The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
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Development of the Heart
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
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Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

