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Hipertrofia septal asimétrica y trastorno de las fibras miocárdicas. Características de los corazones normales, en
Circulation
|August 1, 1977
Resumen
La hipertrofia septal asimétrica (ASH) y el trastorno de la fibra miocárdica no son exclusivos de la estenosis subaórtica hipertrófica idiopática (IHSS). Estos hallazgos ocurren en el desarrollo normal de los corazones y ciertas condiciones congénitas, lo que indica que no son marcadores definitivos para IHSS.
Área de la Ciencia:
- Patología cardiovascular patología cardiovascular.
- Biología del desarrollo Biología del desarrollo.
- Morfología cardíaca morfología cardíaca.
Sus antecedentes:
- La especificidad diagnóstica de la hipertrofia septal asimétrica (ASH) y el trastorno de la fibra miocárdica en la estenosis subaórtica hipertrófica idiopática (IHSS) sigue sin estar clara.
- Comprender los orígenes y la prevalencia de estas características en diversas afecciones cardíacas es crucial para un diagnóstico preciso.
Objetivo del estudio:
- Investigar la ocurrencia y la importancia de la ASH y el desorden de las fibras miocárdicas en una amplia gama de muestras cardíacas.
- Para determinar si estos hallazgos morfológicos son patognomónicos para el IHSS.
Principales métodos:
- Examen histológico de 215 corazones de individuos normales en todas las etapas de desarrollo (de embriones a adultos) y aquellos con enfermedades cardíacas congénitas o adquiridas.
- Análisis comparativo de la morfología septal y la disposición de las fibras miocárdicas en corazones normales versus patológicos.
Principales resultados:
- Se observó un engrosamiento septal desproporcionado (ESA) en todos los embriones y en algunos corazones anormales, particularmente en aquellos con hipertrofia ventricular derecha (HVR).
- El desorden de las fibras miocárdicas estaba presente en todos los corazones en uniones específicas, con un desorden extenso en condiciones como la atresia de la válvula semilunar y la tetralogía de Fallot.
- ASH y un desorden significativo de la fibra se encontraron en condiciones no IHSS.
Conclusiones:
- La hipertrofia septal asimétrica (ASH) es una característica del desarrollo cardíaco normal y puede estar presente en corazones malformados con hipertrofia ventricular derecha (HVR).
- El desorden marcado de la fibra miocárdica puede ocurrir en lesiones cardíacas congénitas asociadas con una contracción sistólica anormal.
- Ni la ASH ni el trastorno de la fibra miocárdica, individualmente o combinados, son características patognomónicas de la estenosis subaórtica hipertrófica idiopática (IHSS).
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