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Diferencias en el control vasomotor entre la arteria mamaria interna gastroepiploica humana y la arteria mamaria
H Buikema1, J G Grandjean, S van den Broek
1Department of Pharamcology/Clinical Pharmacology, University Hospital Groningen, The Netherlands.
Circulation
|November 1, 1992
Resumen
La arteria gastroepiploica y la arteria mamaria interna izquierda muestran respuestas similares a algunas sustancias vasoactivas, pero la arteria gastroepiploica exhibe una mayor relajación a la bradikinina, lo que sugiere posibles diferencias en la función endotelial para el injerto de derivación de la arteria coronaria.
Área de la Ciencia:
- Cirugía vascular Cirugía vascular.
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- La función endotelial es la función endotelial.
Sus antecedentes:
- Los injertos de arteria mamaria interna ofrecen una permeabilidad superior a largo plazo en comparación con los injertos de vena safena.
- Las diferencias de función endotelial entre los vasos arteriales y venosos están implicadas.
- La arteria gastroepiploica se utiliza cada vez más en el injerto de derivación de la arteria coronaria debido a las similitudes con la arteria mamaria interna.
Objetivo del estudio:
- Para comparar las respuestas endoteliales de los injertos de la arteria gastroepiploica y de la arteria mamaria interna izquierda.
- Para investigar sus reacciones a varias sustancias vasoactivas.
Principales métodos:
- Las arterias mamarias internas gastroepiploicas y izquierdas fueron extraídas de pacientes sometidos a cirugía de derivación de la arteria coronaria.
- Los anillos vasculares fueron sometidos a experimentos de baños de órganos.
- Se midieron las respuestas de relajación a la metacolina, el nitrito de sodio y la bradicinina.
Principales resultados:
- Ambas arterias mostraron respuestas de relajación similares a la metacolina y al nitrito de sodio.
- La bradicinina indujo una relajación significativa en los anillos de la arteria gastroepiploica, pero no en los anillos de la arteria mamaria interna izquierda.
- Se observó una correlación negativa entre la edad y la relajación máxima inducida por metacolina en los anillos de la arteria mamaria interna izquierda.
Conclusiones:
- Respuestas similares a la metacolina y al nitrito de sodio sugieren una actividad de la vía de L-arginina comparable en ambas arterias.
- La respuesta diferencial a la bradicinina puede indicar un metabolismo distinto de las prostaglandinas en la arteria gastroepiploica.
- Se observó una relajación dependiente de la edad en la arteria mamaria interna izquierda, a diferencia de la arteria gastroepiploica.
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