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Updated: May 7, 2026
06:32
Deciphering Molecular Mechanism of Histone Assembly by DNA Curtain Technique
Published on: March 9, 2022
La vida secreta de las histonas
David A F Gillespie1, Karen H Vousden
1Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, G61 1BD, Glasgow, United Kingdom.
Cell
|September 25, 2003
Resumen
La histona de enlace H1.2 promueve inesperadamente la apoptosis después del daño del ADN. El H1.2 nuclear se mueve al citoplasma, desencadenando la liberación del citocromo c y la muerte celular programada.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Biología celular Biología celular.
- Genética La genética.
Sus antecedentes:
- Las rupturas de doble cadena de ADN (DSB) son lesiones críticas del ADN que pueden desencadenar vías de muerte celular.
- La histona vinculadora H1.2 es principalmente conocida por su papel en la estructura de la cromatina y la regulación génica.
- La apoptosis, o muerte celular programada, es un proceso biológico fundamental crucial para el desarrollo y la homeostasis tisular.
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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...