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Videos de Conceptos Relacionados

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...

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Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

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A molecular timer couples organism-wide temporal identity to developmental checkpoints.

Proceedings of the National Academy of Sciences of the United States of America·2026
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<i>C. elegans</i> E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death through target-directed miRNA degradation.

bioRxiv : the preprint server for biology·2026
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Non-apoptotic death of the <i>C. elegans</i> linker cell is primed by MYRF-1 activation of <i>pqn-41</i>/polyQ.

bioRxiv : the preprint server for biology·2025
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EOR-1/PLZF promotes WAH-1/AIF-dependent compartment-specific corpse clearance.

Cell death discovery·2025
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CED-3 caspase promotes dismantling but not onset of non-apoptotic linker cell death in <i>C. elegans</i>.

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Radial-glia-to-astrocyte trans-differentiation and astrocyte transcriptional convergence are coordinated by CEH-43/DLX in <i>C. elegans</i>.

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Video Experimental Relacionado

Updated: Jun 19, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Apoptosis: un proceso con un (beta) NAC para la complejidad.

Shai Shaham1

  • 1Laboratory of Developmental Genetics, The Rockefeller University, New York, NY 10021, USA.

Cell
|September 25, 2003
PubMed
Resumen

Los investigadores descubrieron un nuevo inhibidor de la muerte celular programada en C. elegans, llamado icd-1. La pérdida de icd-1 promueve la apoptosis independientemente de la clave ced-3 caspase, revelando una nueva vía de muerte celular.

Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • Biología celular Biología celular.
  • Genética La genética.

Sus antecedentes:

  • La muerte celular programada, o apoptosis, es crucial para el desarrollo y la homeostasis tisular.
  • En el nematodo C. elegans, la apoptosis está regulada principalmente por la ced-3 caspase.
  • Comprender las vías alternativas de muerte celular es esencial para obtener una imagen completa de la regulación de la apoptosis.

Objetivo del estudio:

  • Para identificar nuevos reguladores de la muerte celular programada en C. elegans.
  • Para investigar los mecanismos de la apoptosis que operan independientemente de la actividad de la ced-3 caspase.

Principales métodos:

  • Utilizó pantallas genéticas en C. elegans para identificar mutaciones que afectan la muerte celular.

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Last Updated: Jun 19, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

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Detecting Anastasis In Vivo by CaspaseTracker Biosensor
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Detecting Anastasis In Vivo by CaspaseTracker Biosensor

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Detection and Isolation of Apoptotic Bodies to High Purity
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Detection and Isolation of Apoptotic Bodies to High Purity

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  • Realizó análisis moleculares y celulares para caracterizar la función de los genes identificados.
  • Investigó las interacciones genéticas entre el nuevo gen y los reguladores conocidos de la apoptosis.

    • Principales resultados:

    • Identificó y caracterizó un nuevo gen, icd-1, que codifica un inhibidor de la muerte.
    • Se demostró que las mutaciones de pérdida de función en ICD-1 promueven la apoptosis.
    • Se demostró que la apoptosis mediada por icd-1 ocurre independientemente de la actividad de la ced-3 caspase.

    Conclusiones:

    • icd-1 es un nuevo inhibidor de la muerte celular programada en C. elegans.
    • Existe una vía apoptótica independiente de ced-3 en C. elegans, regulada por icd-1.
    • Este descubrimiento amplía nuestra comprensión de la compleja regulación de la apoptosis.