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Un mecanismo de sensor de nutrientes controla el crecimiento de Drosophila
Julien Colombani1, Sophie Raisin, Sophie Pantalacci
1Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS-Parc Valrose, 06108, Cedex 2, Nice, France.
Cell
|September 25, 2003
Resumen
El cuerpo graso de la Drosophila actúa como un sensor de nutrientes, coordinando el crecimiento del organismo. La regulación a la baja del transportador de aminoácidos resistente en este órgano desencadena defectos sistémicos de crecimiento a través de la señalización humoral.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- La detección de nutrientes es muy sencilla.
- Endocrinología Endocrinología.
Sus antecedentes:
- El crecimiento del organismo requiere la coordinación de las respuestas celulares a la disponibilidad de nutrientes.
- El cuerpo graso del insecto comparte similitudes funcionales con el hígado de los vertebrados, incluidas las funciones endocrinas y de almacenamiento.
Objetivo del estudio:
- Investigar el papel del cuerpo graso de la Drosophila en la coordinación del crecimiento del organismo en respuesta a los niveles de nutrientes.
- Identificar genes y vías de señalización involucradas en esta coordinación.
Principales métodos:
- Pantalla genética para los modificadores del crecimiento en Drosophila.
- Análisis de la función génica (slimfast) utilizando interferencia de ARN (RNAi) específicamente en el cuerpo graso.
- Investigación de las vías de señalización aguas abajo incluyendo TSC/TOR y PI3-kinasa.
Principales resultados:
- Identificación de slimfast, un transportador de aminoácidos, como un modificador clave del crecimiento.
- Regulación a la baja de slimfast en la grasa corporal fenocopias de los defectos de crecimiento del organismo visto bajo la privación de nutrientes.
- La evidencia de la señalización TSC / TOR en el cuerpo graso y la inhibición remota de la señalización de la PI3-cinasa en los tejidos periféricos.
Conclusiones:
- El cuerpo graso de la Drosophila funciona como un sensor central de nutrientes.
- El crecimiento del organismo está regulado por un mecanismo humoral originado en la grasa corporal.
- El cuerpo graso coordina el crecimiento mediante la detección de nutrientes y la modulación de las vías de señalización sistémica.
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