Video Experimental Relacionado
Updated: Aug 12, 2026
08:35
A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
Published on: March 17, 2015
Control del tálamo de la nocicepción visceral mediada por los canales Ca2+ de tipo T
Daesoo Kim1, Donghyun Park, Soonwook Choi
1National Creative Research Initiative Center for Calcium and Learning, Korea Institutes of Science and Technology, Seoul 136-791, Korea.
Science (New York, N.Y.)
|October 4, 2003
Resumen
Los ratones que carecen de canales de calcio tipo T alfa1G muestran una mayor sensibilidad al dolor visceral. Estos canales en el tálamo son cruciales para el control del dolor, previniendo las señales persistentes de dolor.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Investigación del dolor Investigación del dolor.
- Función del canal de calcio Función del canal de calcio
Sus antecedentes:
- Las sensaciones viscerales pueden volverse dolorosas con estímulos persistentes.
- Los canales de calcio tipo T Alpha1G están implicados en las vías del dolor.
Objetivo del estudio:
- Para investigar el papel de los canales de calcio tipo T alfa1G en el procesamiento del dolor visceral.
- Para explorar la participación del tálamo en el control sensorial durante el dolor visceral.
Principales métodos:
- Se utilizaron ratones alfa1G tipo T con deficiencia de canales de calcio.
- Bloqueadores de los canales de calcio tipo T administrados a ratones de tipo salvaje.
- Se registra la actividad neuronal en el tálamo ventroposterolateral.
Principales resultados:
- Los ratones con deficiencia de alfa1G mostraron hiperalgesia al dolor visceral.
- El bloqueo de los canales del tipo T del tálamo indujo hiperalgesia similar.
- Las neuronas tálamicas exhibieron patrones de disparo alterados (picos únicos frente a picos de explosión) en ratones con deficiencia.
Conclusiones:
- Los canales de calcio tipo T en el tálamo median un mecanismo antinociceptivo.
- El disparo de ráfagas neuronales en el tálamo es crítico para bloquear las señales de dolor visceral.
Videos de Conceptos Relacionados
01:43Thermosensation
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
01:44Nociception
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
01:12Mechanically-gated Ion Channels
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
01:25Analgesia and Pain Management
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
01:20Pain
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...