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La captación celular de los aminoglucósidos, los guanidinoglucósidos y la poliarginina

Nathan W Luedtke1, Peter Carmichael, Yitzhak Tor

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.

Journal of the American Chemical Society
|October 9, 2003
PubMed
Resumen

Las drogas aminoglucósidas como la neomicina B y la tobramicina tienen una absorción celular pobre. La conversión de sus aminas en grupos de guanidina mejora significativamente la absorción celular, mejorando el potencial de administración de fármacos.

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