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Updated: Aug 4, 2026
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Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
Published on: April 14, 2011
Epidemiología de las infecciones neumocócicas invasivas en niños en Finlandia
1Department of Infectious Disease Epidemiology, National Public Health Institute, Helsinki, Finland.
JAMA
|December 16, 1992
Resumen
Las infecciones neumocócicas invasivas son comunes en los niños finlandeses, especialmente los menores de cinco años. Una vacuna dirigida podría prevenir hasta el 70% de estas infecciones graves.
Área de la Ciencia:
- Enfermedades Infecciosas Pediátricas
- Epidemiología La epidemiología.
- Vacunología Vacunología.
Sus antecedentes:
- Streptococcus pneumoniae causa infecciones invasivas significativas en los niños.
- Comprender las características de la infección es crucial para desarrollar estrategias efectivas de vacunación.
Objetivo del estudio:
- Caracterizar la epidemiología de las infecciones neumocócicas invasivas en niños en Finlandia.
- Proporcionar datos para informar el desarrollo de los programas de vacunación contra Streptococcus pneumoniae.
Principales métodos:
- Prospectiva, a nivel nacional, basado en la vigilancia de laboratorio de las infecciones neumocócicas invasivas en niños (0-15 años) desde 1985-1989.
- Datos recogidos de todos los laboratorios microbiológicos y salas pediátricas finlandesas.
- Infecciones confirmadas por el aislamiento de Streptococcus pneumoniae de la sangre, el líquido cefalorraquídeo o las aspiraciones profundas.
Principales resultados:
- Se diagnosticaron 452 infecciones neumocócicas invasivas.
- Las tasas de incidencia fueron 8.9/100.000 niños (<16 años), 24.2/100.000 (<5 años) y 45.3/100.000 (<2 años).
- Las presentaciones clínicas más comunes incluyeron bacteriemia sin foco (310), neumonía (66) y meningitis (51).
- Los serotipos 14, 6, 19, 7, 18 y 23 representaron el 78% de las infecciones.
Conclusiones:
- Streptococcus pneumoniae es una causa frecuente de infecciones invasivas en niños finlandeses.
- Una vacuna neumocócica conjugada dirigida a los seis serotipos más prevalentes podría potencialmente prevenir hasta el 70% de las infecciones invasivas en niños si se administra durante la infancia.
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