Video Experimental Relacionado
Updated: Jun 29, 2026
10:38
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
El ritmo circadiano. Los relojes de regeneración del hígado están encendidos
1Department of Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland. ueli.schibler@molbio.unige.ch
Science (New York, N.Y.)
|October 11, 2003
Resumen
El reloj del ciclo celular de los mamíferos, como el de los organismos simples, está regulado por el oscilador circadiano maestro. Este hallazgo revela un vínculo fundamental entre los ritmos diarios y la división celular en los mamíferos.
Área de la Ciencia:
- Cronobiología cronobiología.
- Biología celular Biología celular.
- Fisiología de los mamíferos Fisiología de los mamíferos
Sus antecedentes:
- El reloj del ciclo celular controla la división celular.
- En los organismos simples, los ritmos circadianos influyen en el tiempo de división celular.
- La relación entre los ritmos circadianos y el ciclo celular en los mamíferos es menos comprendida.
Objetivo del estudio:
- Para investigar si el oscilador circadiano maestro influye en el reloj del ciclo celular en las células de mamíferos.
- Para explorar la regulación temporal de la división celular en los mamíferos.
Principales métodos:
- Estudió la regeneración de las células hepáticas en ratones.
- Utilizó técnicas moleculares y genéticas para evaluar el control circadiano sobre la progresión del ciclo celular.
Principales resultados:
- Demostrado que el reloj del ciclo celular en las células hepáticas de mamíferos es de hecho influenciado por el oscilador circadiano maestro.
- Identificó ventanas temporales específicas para la división celular dictada por las señales circadianas.
Conclusiones:
- El reloj circadiano juega un papel crucial en la regulación del tiempo de la división celular en las células de los mamíferos.
- Esto sugiere un mecanismo conservado que vincula los ritmos diarios a la proliferación celular en diversas especies.
Videos de Conceptos Relacionados
02:45Biological Clocks and Seasonal Responses
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
01:23Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
01:24Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...