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Videos de Conceptos Relacionados

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Video Experimental Relacionado

Updated: Jul 22, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

La genómica. la genómica. la genómica. la genómica. la genómica. la genómica. Microarrays--culpado por asociación.

John Quackenbush1

  • 1The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. johnq@tigr.org

Science (New York, N.Y.)
|October 11, 2003
PubMed
Resumen

El análisis de microarrays de ADN revela patrones de expresión génica, pero tiene dificultades para identificar redes de genes. Una nueva investigación aprovecha la conservación evolutiva entre especies para identificar grupos de genes funcionalmente relacionados.

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Área de la Ciencia:

  • La genómica es la genómica.
  • La bioinformática es la bioinformática.
  • Biología evolutiva Biología evolutiva.

Sus antecedentes:

  • La tecnología de microarrays de ADN ofrece extensos datos de expresión génica.
  • Identificar redes de productos genéticos que interactúan sigue siendo un desafío.
  • Los métodos anteriores no han realizado completamente el potencial de los datos de expresión génica para el análisis de redes.

Objetivo del estudio:

  • Explorar nuevos métodos para identificar grupos de genes funcionalmente relacionados.
  • Para utilizar la conservación evolutiva de los patrones de expresión génica para el descubrimiento biológico.
  • Para avanzar en la comprensión de las interacciones de los productos genéticos.

Principales métodos:

  • Análisis de patrones de expresión génica en múltiples especies, incluidas levaduras, gusanos, moscas de la fruta y humanos.
  • Aplicación de los principios de conservación evolutiva a los datos de expresión génica.
  • Utilizando enfoques computacionales para identificar las relaciones funcionales conservadas.

Principales resultados:

  • El estudio demuestra un método para identificar genes funcionalmente relacionados basados en patrones de expresión conservados.
  • La conservación evolutiva proporciona un marco sólido para inferir la función e interacciones de los genes.
  • Este enfoque ofrece una nueva vía para diseccionar complejas redes biológicas.

Conclusiones:

  • Los patrones de expresión génica conservados en todas las especies son un poderoso indicador de la relación funcional.
  • Esta metodología mejora la capacidad de identificar redes de genes a partir de datos de expresión a gran escala.
  • Los hallazgos contribuyen a una comprensión más profunda de la función génica y las relaciones evolutivas.