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La aldosterona regula la reactividad vascular: efectos a corto plazo mediados por la activación de la sintasa de
Selina L Liu1, Saskia Schmuck, Jozef Z Chorazcyzewski
1Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Circulation
|October 15, 2003
Resumen
La aldosterona afecta rápidamente la función de los vasos sanguíneos. Relaja los vasos con el endotelio intacto, pero contrae los que no lo tienen, lo que afecta la resistencia vascular y las enfermedades cardiovasculares.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Endocrinología Endocrinología.
- Biología Vascular Biología Vascular
Sus antecedentes:
- La evidencia emergente sugiere efectos rápidos y no genómicos de la aldosterona.
- El impacto inmediato de la aldosterona en la reactividad vascular requiere más investigación.
Objetivo del estudio:
- Para investigar los efectos inmediatos de la aldosterona en la reactividad vascular en anillos aórticos de rata.
- Para examinar las respuestas celulares de la aldosterona en las células musculares lisas endoteliales y vasculares.
Principales métodos:
- Se utilizaron segmentos de anillo aórtico de rata (endotelio intacto y desnuda) para evaluar la reactividad vascular.
- Investigó las vías de señalización celular, incluida la actividad de la sintasa de óxido nítrico y la activación de la quinasa, en las células endoteliales.
Principales resultados:
- Constricción inducida por fenilefrina atenuada con aldosterona en anillos intactos del endotelio.
- La aldosterona aumentó la vasoconstricción en los vasos endotélicos desnudos.
- En las células endoteliales, la aldosterona aumentó la actividad de la óxido nítrico sintasa y activó la ERK1/2 y la p70 S6 quinasa a través de PI3K.
Conclusiones:
- La aldosterona ejerce efectos novedosos y rápidos en las células vasculares endoteliales y del músculo liso.
- Estas acciones rápidas pueden desempeñar un papel en la regulación de la resistencia vascular periférica.
- Las respuestas alteradas de aldosterona en la disfunción endotelial podrían contribuir a la patogénesis de enfermedades cardiovasculares.
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