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Videos de Conceptos Relacionados

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Recombinant DNA01:09

Recombinant DNA

Overview
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Mutations in Microorganisms01:18

Mutations in Microorganisms

Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...

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Video Experimental Relacionado

Updated: Jul 16, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
09:13

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

Vacunología inversa y genómica.

Rino Rappuoli1, Antonello Covacci

  • 1IRIS, Chiron Vaccines, 53100 Siena, Italy.

Science (New York, N.Y.)
|October 25, 2003
PubMed
Resumen

La revolución genómica acelera el desarrollo de vacunas al permitir el descubrimiento de nuevos objetivos de vacunas. Este avance es crucial para crear vacunas más efectivas contra diversas enfermedades.

Área de la Ciencia:

  • La genómica es la genómica.
  • Inmunología Inmunología.
  • Vacunología Vacunología.

Sus antecedentes:

  • La revolución genómica ha transformado las ciencias biológicas.
  • Comprender los genomas de los patógenos es clave para identificar candidatos a vacunas.

Objetivo del estudio:

  • Para resaltar el impacto de la genómica en el descubrimiento de objetivos de vacunas.
  • Para discutir el desarrollo de nuevas y efectivas vacunas.

Principales métodos:

  • Secuenciación y análisis genómicos.
  • Enfoques bioinformáticos para la identificación de objetivos.
  • Validación in silico e in vitro de los objetivos de las vacunas.

Principales resultados:

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Videos de Experimentos Relacionados

Last Updated: Jul 16, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
09:13

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins
11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Reverse Genetics to Engineer Positive-Sense RNA Virus Variants
15:49

Reverse Genetics to Engineer Positive-Sense RNA Virus Variants

Published on: June 9, 2022

  • Los datos genómicos han ampliado significativamente el repertorio de posibles objetivos de vacunas.
  • Están surgiendo nuevas estrategias para el desarrollo de vacunas basadas en conocimientos genómicos.
  • La mejora de la eficacia de las vacunas se está logrando a través de enfoques centrados en el objetivo.

    • Conclusiones:

    • La revolución genómica es una fuerza fundamental en la vacunología moderna.
    • La integración continua de las tecnologías genómicas impulsará la innovación futura de vacunas.
    • Las estrategias basadas en el genoma prometen una mayor protección contra las enfermedades infecciosas.