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Updated: Jul 5, 2026

Interview: Protein Folding and Studies of Neurodegenerative Diseases
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Las vías moleculares de la neurodegeneración en la enfermedad de Parkinson

Ted M Dawson1, Valina L Dawson

  • 1Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. tdawson@jhmi.edu

Science (New York, N.Y.)
|November 1, 2003
PubMed
Resumen

La enfermedad de Parkinson (EP) puede derivarse de la inhibición del complejo I mitocondrial, lo que lleva a la agregación de alfa-sinucleína y la muerte de las neuronas de dopamina. Las terapias dirigidas al complejo I, el estrés oxidativo y el manejo de proteínas son prometedoras para la neuroprotección en la EP.

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