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Chorioamnionitis y parálisis cerebral en bebés a término y cerca del término
Yvonne W Wu1, Gabriel J Escobar, Judith K Grether
1Department of Neurology, University of California, San Francisco 94143, USA. wuy@peds.ucsf.edu
JAMA
|December 4, 2003
Resumen
La coriamnionitis clínica es un factor de riesgo independiente para la parálisis cerebral (PC) en los bebés a término y a corto plazo. Este hallazgo pone de relieve la importancia de abordar la corioamnionitis para reducir la incidencia de PC.
Área de la Ciencia:
- Neurología Neurología.
- Obstetricia y obstetricia.
- La pediatría es la medicina de los niños.
Sus antecedentes:
- La parálisis cerebral (PC) afecta a muchos bebés a término, sin embargo, los factores de riesgo siguen sin estar claros.
- La evidencia emergente sugiere que la corioamnionitis puede desempeñar un papel en el desarrollo de la CP.
Objetivo del estudio:
- Investigar la asociación entre la coriomionitis clínica y el riesgo de PC en los bebés a término y a corto plazo.
Principales métodos:
- Se realizó un estudio de caso-control dentro de una gran cohorte de bebés nacidos en ≥36 semanas de gestación.
- Los casos fueron niños con parálisis cerebral de moderada a grave; los controles fueron seleccionados al azar.
- La corioamnionitis clínica fue diagnosticada por los médicos tratantes.
Principales resultados:
- La coriomionitis estuvo presente en el 14% de los casos de PC frente al 4% de los controles (OR, 3.8).
- Los factores de riesgo independientes para la PC incluyen corioamnionitis (OR, 4.1), restricción del crecimiento intrauterino, etnia materna, edad materna y nulliparidad.
- La corioamnionitis representó el 11% de la fracción atribuible a la población para la PC.
Conclusiones:
- La corioamnionitis clínica es un factor de riesgo independiente para la parálisis cerebral en los bebés a término y a corto plazo.
- Estos hallazgos subrayan la necesidad de intervenciones dirigidas a la coriomionitis para prevenir la PC.
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