Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Mate Choice01:20

Mate Choice

Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Natural Selection and Mating Preferences01:06

Natural Selection and Mating Preferences

The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing, inherently...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells.

Science immunology·2019
Same author

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

Mucosal immunology·2016
Same author

Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.

Mucosal immunology·2015
Same author

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells.

Immunology and cell biology·2014
Same author

IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.

Mucosal immunology·2014
Same author

Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy.

Clinical and experimental immunology·2013

Video Experimental Relacionado

Updated: Jul 16, 2026

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

Una línea celular que puede inducir la selección positiva del timocito.

P Hugo1, J W Kappler, D I Godfrey

  • 1Howard Hughes Medical Institute, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.

Nature
|December 17, 1992
PubMed
Resumen

Este estudio muestra que células epiteliales tímicas específicas pueden seleccionar células T. Estas células presentan antígenos a través de las proteínas del complejo mayor de histocompatibilidad (MHC), que guían el desarrollo de las células T.

Más Videos Relacionados

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Videos de Experimentos Relacionados

Last Updated: Jul 16, 2026

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation
09:23

A Rapid Filter Insert-based 3D Culture System for Primary Prostate Cell Differentiation

Published on: February 13, 2017

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells
08:05

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Área de la Ciencia:

  • Inmunología Inmunología.
  • Biología celular Biología celular.

Sus antecedentes:

  • El timo es crucial para el desarrollo de las células T, lo que implica una selección positiva.
  • La selección positiva asegura que las células T reconozcan las proteínas auto-mayores del complejo de histocompatibilidad (MHC).
  • Los tipos específicos de células que median la selección positiva del timo aún no se comprenden por completo.

Objetivo del estudio:

  • Investigar si las células epiteliales tímicas especializadas median la selección positiva de las células T.
  • Para determinar si las células epiteliales introducidas pueden apoyar la selección positiva.

Principales métodos:

  • Los ratones irradiados fueron reconstituidos con médula ósea o células hepáticas fetales.
  • Se introdujo una línea de células epiteliales tímicas que expresan H-2b en ratones receptores de H-2k.
  • Se analizó el reconocimiento y la restricción del receptor de células T.

Principales resultados:

  • La presencia de células T restringidas por I-Ab se detectó en animales receptores.
  • Esto indica que las células epiteliales que expresan H-2b introducidas mediaron con éxito la selección positiva.
  • Demuestra la capacidad de células epiteliales específicas en la selección de células T.

Conclusiones:

  • Las células epiteliales tímicas específicas son suficientes para mediar la selección positiva de las células T.
  • Este hallazgo aclara la base celular del desarrollo de las células T dentro del timo.
  • Destaca el papel de los subconjuntos de células epiteliales en la inmunidad adaptativa.