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Updated: Jul 9, 2026

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
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Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling

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Un inhibidor basado en el mecanismo dirigido a la actividad de la DD-transpeptidasa de las proteínas bacterianas que

Mijoon Lee1, Dusan Hesek, Maxim Suvorov

  • 1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.

Journal of the American Chemical Society
|December 25, 2003
PubMed
Resumen

El Compuesto 6, un nuevo derivado de la cefalosporina, es el primer inhibidor diseñado específicamente para las DD-transpeptidasas. Inhibe irreversiblemente PBP1b, una enzima clave en la síntesis de la pared celular bacteriana, pero no afecta a PBP5.

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