Video Experimental Relacionado
Updated: Jul 17, 2026
08:01
Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
Published on: May 30, 2012
Foxg1 suprime el destino temprano de las células corticales
Carina Hanashima1, Suzanne C Li, Lijian Shen
1Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA.
Science (New York, N.Y.)
|January 6, 2004
Resumen
El factor de transcripción Foxg1 suprime la generación de neuronas Cajal-Retzius nacidas temprano durante el desarrollo del cerebro de los mamíferos. La pérdida de Foxg1 conduce a una sobreproducción de estas neuronas cruciales.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología del desarrollo Biología del desarrollo.
- Genética La genética.
Sus antecedentes:
- La corticogénesis cerebral de los mamíferos implica que las células progenitoras restrinjan progresivamente la salida neuronal.
- Los mecanismos moleculares que gobiernan el destino de las neuronas nacidas prematuramente frente a las neuronas nacidas tarde siguen sin estar claros.
Objetivo del estudio:
- Para investigar la regulación molecular de la producción de neuronas de nacimiento temprano durante la corticogénesis.
- Identificar el papel del factor de transcripción Foxg1 en la determinación del destino neuronal.
Principales métodos:
- Utilizó ratones mutantes nulos Foxg1 para observar los efectos en la producción de neuronas Cajal-Retzius.
- Inactivación condicional empleada de Foxg1 en poblaciones específicas de progenitoras corticales.
Principales resultados:
- Los mutantes nulos de Foxg1 exhibieron un exceso de producción de neuronas Cajal-Retzius en la corteza.
- Requisito constitutivo de Foxg1 para suprimir el destino celular de Cajal-Retzius demostrado a través de la inactivación condicional.
Conclusiones:
- El factor de transcripción Foxg1 suprime activamente el destino celular de Cajal-Retzius durante la corticogénesis.
- El potencial para generar neuronas nacidas temprano se reprime activamente, no se pierde, durante el desarrollo cortical posterior.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:33Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
01:16TGF - β Signaling Pathway
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
01:10Zygotic Development And Stem Cell Formation
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
01:12Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
01:23Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...