Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

A working model for CCN3 C-terminal domain-mediated transcriptional modulation of the plasminogen activation system.

Journal of cell communication and signaling·2026
Same author

Species-specific roles of cellular communication network proteins in cartilage development: A comparative study using in vitro chondrogenic models.

Journal of cell communication and signaling·2026
Same author

CCN3 as a moonlighting signaling protein: a potential model for dual nuclear and extracellular functions across the CCN family.

Cell communication and signaling : CCS·2026
Same author

Celebrating milestones in cell communication and signaling: Forthcoming joint ICCNS-ARBIOCOM anniversary meeting.

Journal of cell communication and signaling·2025
Same author

I had a dream.

Journal of cell communication and signaling·2025
Same author

The case of Connective Tissue Growth Factor (CTGF) and the pit of misleading and improper nomenclatures.

Journal of cell communication and signaling·2024
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jul 6, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Las proteínas CCN: reguladores de señalización multifuncionales.

Bernard Perbal1

  • 1Laboratoire d'Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7-D Diderot, 75005, Paris, France. perbal@ccr.jussieu.fr

Lancet (London, England)
|January 16, 2004
PubMed
Resumen
Este resumen es generado por máquina.

El factor de crecimiento del tejido conectivo (CCN2) actúa como un factor de adhesión celular para las células esteladas hepáticas. Sus distintas isoformas se unen de manera diferente a la LRP, influyendo en la señalización celular y la actividad biológica.

Más Videos Relacionados

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

In Vivo Calcium Imaging in C. elegans Body Wall Muscles
08:03

In Vivo Calcium Imaging in C. elegans Body Wall Muscles

Published on: October 20, 2019

Videos de Experimentos Relacionados

Last Updated: Jul 6, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

In Vivo Calcium Imaging in C. elegans Body Wall Muscles
08:03

In Vivo Calcium Imaging in C. elegans Body Wall Muscles

Published on: October 20, 2019

Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Biología celular Biología celular.
  • La medicina molecular es una medicina molecular.

Sus antecedentes:

  • Las proteínas de la matriz, incluida la familia CCN (cyr61, ctgf, nov), son cruciales para la señalización celular, la proliferación y la diferenciación.
  • CCN2 (factor de crecimiento del tejido conectivo) se identifica como un factor clave de adhesión celular para las células esteladas hepáticas.
  • Las células esteladas hepáticas producen distintas isoformas de CCN2 tras la exposición al factor de crecimiento transformador beta.

Objetivo del estudio:

  • Para investigar las propiedades de adhesión celular de las isoformas de CCN2 en células esteladas hepáticas.
  • Aclarar el papel de módulos específicos de CCN2 en la unión a la proteína relacionada con el receptor de lipoproteínas de baja densidad (LRP).
  • Comprender cómo la unión diferencial de las isoformas de CCN2 a LRP afecta las actividades biológicas y la señalización.

Principales métodos:

  • Análisis de la producción de isoformas CCN2 por células esteladas hepáticas.
  • Caracterización de las interacciones del módulo CCN2 con el LRP.
  • Investigación de los mecanismos de unión dependientes de la heparina entre CCN2 y LRP.

Principales resultados:

  • CCN2 actúa como un factor de adhesión celular para las células esteladas hepáticas.
  • El módulo 3 de CCN2 media la unión dependiente de la heparina a la LRP.
  • El módulo 4 de CCN2 promueve la adhesión independiente de la LRP.
  • La unión diferencial de las isoformas de CCN2 a LRP sugiere actividades agonistas o antagonistas dependientes del contexto.

Conclusiones:

  • La configuración específica de las isoformas de CCN2 influye en sus actividades biológicas y biodisponibilidad.
  • Comprender la base estructural de la multifuncionalidad de CCN2 es vital para su aplicación en medicina molecular.
  • Es esencial una mayor investigación sobre los mecanismos de producción de isoformas truncadas de CCN.